We transform any smartphone into a measurement laboratory for precision medicine development
The Opportunity to Enhance Precision in Neurology
Clinical scales
Subjective
Imprecise
In-clinic
Infrequent
Conventional data points — in clinic visits
Digital endpoints
Objective
More Accurate & Functional
In-clinic + Home + Ecological
Higher Sampling Frequency
Tech-enabled data points — in daily life
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A digital endpoint can reduce sample size and/or augment probability of success (PoS) of R&D proof-of-concept (PoC) trials through two strategies:
Use a digital measurement with higher Signal-to-Noise Ratio (SNR) as a decision-enabling proof-of-concept (PoC) trial endpoint.
Does not have to be fully convergent with reference measurement, while enhancing the end of Phase II decision trees to optimise probability of success (PoS) in Phase III.
Use higher longitudinal frequency of digital measurements that correlate with the reference measurement
These digital markers can then help “explain” the variation, reduce the noise, and increase the SNR for the reference measurement.
Through our multi-year strategic collaboration with Biogen, we aim to expand the reach of our unique technology into Parkinson’s disease, a critical disease area where innovation is crucially needed.
The extension of our work into Parkinson’s disease may cross-fertilize with the progress of our scientific efforts in Multiple Sclerosis.
Indivi's focus on digital endpoint development spans across key neurodegenerative disorders, including Alzheimer’s disease, and related dementias.
The Scientific and Clinical Team
An intersection of knowledges and experiences.
A Unique Quality Control Embedded in the Data Science Pipeline
In remote unsupervised settings of sensor data collection, precision is about quality, quality, and quality.
Ground Truth Reference Adjustment of the Feature Extraction Pipeline
All our measurements are technically validated across a wide variety of smartphone hardwares in our in-house ground truth laboratory
End-to-End digital endpoint development technology for RCTs
Indivi provides comprehensive services throughout clinical trials, from protocol design to regulatory and scientific reporting, aimed at developing innovative digital endpoints tailored to the disease and context of use
Schedule of assessments, sample size & power calculation, innovative designs
Adaptive interim analyses, responsive digital measure identification
SAP preparation, final & post-hoc statistical analysis
Indivi's capabilities enable international deployment, comprehensive neurological measurement of neurological functions and compliant, high-quality data collection, storage, analysis and monitoring
Movement
Cognition
Vision
Dexterity
Voice
Comprehensive neurological
function coverage
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Spanish
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Deployment capabilities in 30 countries and 26 languages
Adherence, data quality and test execution correctness monitoring
Regulatory compliant data transfer,
processing and analysis