Advancing early-phase
trial design
Advancing early-phase
trial design
Advancing early-phase
trial design
Design smaller trials with greater confidence in
detecting treatment effects through precise,
high-frequency measurement
Design smaller trials with greater confidence in
detecting treatment effects through precise,
high-frequency measurement
More frequent measurement. Greater precision.
More frequent measurement. Greater precision.
More frequent measurement. Greater precision.
Smaller trials. Increased statistical power.
Smaller trials. Increased statistical power.
Smaller trials. Increased statistical power.
Higher signal-to-noise measurement can reduce the sample size needed to detect a treatment effect or increase statistical power at a given sample size
Higher signal-to-noise measurement can reduce the sample size needed to detect a treatment effect or increase statistical power at a given sample size
Higher signal-to-noise measurement can reduce the sample size needed to detect a treatment effect or increase statistical power at a given sample size
Explore the impact on trial design
Explore the impact on trial design
Explore the impact on trial design
Based on our work in Parkinson’s disease, explore the simulated impact of precise, high-frequency measurement on sample size and statistical power
Scientific partnership from trial design to analysis
Scientific partnership from trial design to analysis
Scientific partnership from trial design to analysis
We support sponsors from study protocol design through analysis and regulatory and scientific reporting, helping integrate precision measures into early-phase trials
We support sponsors from study protocol design through analysis and regulatory and scientific reporting, helping integrate precision measures into early-phase trials
Trial design
Trial design
Endpoint selection, assessment schedule, sample size and power calculations
Endpoint selection, assessment schedule, sample size and power calculations
Trial conduct
Trial conduct
Measure deployment, adherence monitoring, and quality control
Measure deployment, adherence monitoring, and quality control
Analysis and reporting
Analysis and reporting
Statistical analysis plans, interim and final analyses, reports and publications
Statistical analysis plans, interim and final analyses, reports and publications
Built for international clinical trials
Built for international clinical trials
Built for international clinical trials
Comprehensive motor and cognitive measurement
Comprehensive motor and cognitive measurement
Deployed in 30 countries and 14 languages
Deployed in 30 countries and 14 languages
Adherence and data quality monitoring
Adherence and data quality monitoring
Secure data transfer, processing, and analysis
Secure data transfer, processing, and analysis
The Scientific and Clinical Team
The Scientific and Clinical Team
The Scientific and Clinical Team
Emmanuel Bartholomé, MD
Emmanuel Bartholomé, MD
Head of Clinical Development
Head of Clinical Development
Neurologist and Rehabilitation Specialist, Medical Director of Digital Biomarker Clinical Strategy, Biogen Digital Health (2021-2023)
Head of Neurology Department (CHU Tivoli, BE) and MS Clinical Trial Investigator (2008-2021)
Neurologist and Rehabilitation Specialist, Medical Director of Digital Biomarker Clinical Strategy, Biogen Digital Health (2021-2023)
Head of Neurology Department (CHU Tivoli, BE) and MS Clinical Trial Investigator (2008-2021)
Corrado Bernasconi, MD PhD
Corrado Bernasconi, MD PhD
Head of Biostatistics
Head of Biostatistics
Statistician and Computational Neuroscientist Senior Biostatistician at F. Hoffmann-La Roche AG (2005-2023)
Co-Head of the Neuroscience Clinical Trial Unit, University of Bern (2014-2021)
Statistician and Computational Neuroscientist Senior Biostatistician at F. Hoffmann-La Roche AG (2005-2023)
Co-Head of the Neuroscience Clinical Trial Unit, University of Bern (2014-2021)
Claudia Mazzà, PhD
Claudia Mazzà, PhD
Head of Research
Head of Research
Professor of Biomechanics, The University of Sheffield (UK), Department of Mechanical Engineering (2019-Present)
Executive Director of Insigneo Institute for in silico Medicine (Sheffield, 2019-2020) Work Package Leader of Mobilise-D
Professor of Biomechanics, The University of Sheffield (UK), Department of Mechanical Engineering (2019-Present)
Executive Director of Insigneo Institute for in silico Medicine (Sheffield, 2019-2020) Work Package Leader of Mobilise-D
Óscar Gabriel Reyes Pupo, PhD
Óscar Gabriel Reyes Pupo, PhD
Head of Data Science & Signal Processing
Head of Data Science & Signal Processing
Assistant Professor of Computer Science and Artificial Intelligence at the University of Holguín, Cuba (2008–2016)
Assistant Professor at The Maimonides Institute of Biomedical Research of Córdoba (IMIBIC, 2017-2020)
Assistant Professor of Computer Science and Artificial Intelligence at the University of Holguín, Cuba (2008–2016)
Assistant Professor at The Maimonides Institute of Biomedical Research of Córdoba (IMIBIC, 2017-2020)
